Born in Biên Hòa, Vietnam, Do moved to Philadelphia with his parents at the age of 14. A love for fashion, cultivated on the internet, led him to FIT and then to the Céline atelier where he worked under Phoebe Philo. He launched his own namesake label in 2018, which stepped into the post-Philo void for clean, luxurious daywear for women with impeccable taste, and which soon caught on with men like Moses Sumney and Jeno from NCT. On May 13, 2023, he was announced as the new Creative Director of Helmut Lang.